In the ongoing battle against excess weight, one of the biggest obstacles is hunger. Cravings and constant snacking can derail even the best diet intentions. That’s why appetite suppressants have become increasingly popular. But how do they actually work, and are they safe? In this in-depth guide, we’ll uncover the truth about appetite suppressants—what works, what doesn’t, and how to use them responsibly to support your weight loss goals.
What Are Appetite Suppressants?
Appetite suppressants are substances—either natural or synthetic—that help reduce your hunger levels, making it easier to consume fewer calories. They may work by:
- Affecting neurotransmitters like serotonin or norepinephrine
- Expanding in the stomach to create a feeling of fullness
- Regulating blood sugar and insulin response
Some are available as prescription medications, while others are sold as over-the-counter dietary supplements.
Types of Appetite Suppressants
1. Prescription Drugs
These are typically prescribed for individuals with obesity or serious weight-related health risks. Common examples include:
- Phentermine
- Contrave (bupropion/naltrexone)
- Saxenda (liraglutide) These are effective but may come with side effects and require medical supervision.
2. Natural Supplements
Over-the-counter appetite suppressants include herbal ingredients, fibers, and amino acids. Popular examples:
- Glucomannan – A water-soluble fiber that expands in the stomach
- 5-HTP – May help increase serotonin to reduce emotional eating
- Green Tea Extract – May indirectly reduce appetite via energy balance
- Garcinia Cambogia – Controversial; some studies suggest it can inhibit fat formation and reduce hunger
3. Dietary Strategies
You can also reduce appetite through what and how you eat:
- High-protein meals increase satiety
- Fiber-rich foods slow digestion
- Drinking water before meals may reduce food intake
How Effective Are Appetite Suppressants?
Effectiveness varies by individual, type of suppressant, and adherence to overall lifestyle changes. Prescription medications tend to be more powerful but carry greater risk. Natural suppressants often work more gently but can still be effective when combined with calorie control and exercise.
Clinical studies suggest:
- Glucomannan may reduce appetite and support modest weight loss
- 5-HTP may help reduce carb cravings
- Green tea may slightly reduce hunger while boosting fat burning
However, many over-the-counter supplements exaggerate their claims. Be cautious of marketing hype.
Safety and Side Effects
Type | Potential Side Effects |
Prescription Drugs | Increased heart rate, insomnia, anxiety, constipation |
Stimulant Supplements | Jitters, headaches, elevated blood pressure |
Fiber-Based Supps | Bloating, gas, GI discomfort |
Serotonin Boosters | Possible interactions with antidepressants or SSRIs |
Important: Always talk to your doctor before starting any appetite suppressant, especially if you have existing health conditions or take medications.
How to Use Appetite Suppressants Responsibly
- Don’t rely on them alone – They should support, not replace, healthy eating.
- Cycle your use – Use intermittently to prevent adaptation and maintain sensitivity.
- Watch for signs of overuse – If you’re skipping meals or feeling constantly jittery, take a break.
- Combine with behavioral strategies – Mindful eating, stress reduction, and hydration can improve results.
Appetite Suppressants in SlimJaro
SlimJaro combines gentle natural appetite suppressants like glucomannan and green tea extract. This combination helps reduce hunger without relying heavily on stimulants, making it suitable for people sensitive to caffeine.
Learn more in our full SlimJaro Review and see if it’s the right fit for your fat loss plan.
Dr. Ryan Cooper is a physician affiliated with Duke University and Duke University Health System. He specializes in internal medicine and serves as an intern within the Department of Medicine. His education includes medical training at Drexel University College of Medicine, followed by residency at Penn State Hershey Medical Center. Dr. Cooper is board-certified by the American Board of Internal Medicine and is a member of professional organizations such as the American College of Physicians and the Society of Hospital Medicine. His research includes publications on acute kidney injury and renal oxalosis, emphasizing his expertise in internal medicine and nephrology.